Indlela elwa nokuvuvukala ne-antioxidant enezinhlangothi ezimbili - isithako sokunakekelwa kwesikhumba semvelo, i-phloretin!

1.-Iyini i-phloretin-

I-Phloretin(Igama lesiNgisi: I-Phloretin), eyaziwa nangokuthi i-trihydroxyphenolacetone, ingeye-dihydrochalcones phakathi kwe-flavonoids. Igxile kuma-rhizomes noma izimpande zama-apula, ama-strawberries, amapheya nezinye izithelo nemifino ehlukahlukene. Iqanjwe ngesikhumba. Incibilika kusisombululo se-alkali, incibilika kalula ku-methanol, ethanol ne-acetone, futhi cishe ayincibiliki emanzini.

I-Phloretin ingamuncwa ngokuqondile ngumzimba womuntu, kodwa ezitshalweni, incane kakhulu i-phloretin eyenzeka ngokwemvelo. I-Phloretin itholakala kakhulu ngesimo sokuphuma kwayo ku-glycoside, i-phhlorizin. I-phloretin emuncwa umzimba womuntu itholakala kulwelwesi lwesisu. Kuphela ngemva kokuba iqembu le-glycoside lisusiwe ukuze kukhiqizwe i-phloretin lingangena ohlelweni lokujikeleza futhi libe nomphumela walo.

Igama lekhemikhali: 2,4,6-trihydroxy-3-(4-hydroxyphenyl)propiophenone

Ifomula yemolekyuli: C15H14O5

Isisindo se-molecule: 274.27

2.-Imisebenzi esemqoka ye-phloretin-

i-anti-oxidation

Ama-Flavonoid anomsebenzi wokulwa ne-oxidation wamafutha, okuye kwaqinisekiswa ekuqaleni kwawo-1960: izakhiwo ze-polyhydroxyl zama-flavonoid amaningi zingaba nezakhiwo ezibalulekile ze-antioxidant ngokuchela ngama-ion ensimbi.

I-Phloretin iyi-antioxidant yemvelo enhle kakhulu. Isakhiwo se-2,6-dihydroxyacetophenone sinomphumela omuhle kakhulu we-antioxidant. Inomphumela osobala ekukhipheni i-peroxynitrite futhi ine-antioxidant ephezulu emafutheni. Phakathi kuka-10 no-30PPm, ingasusa ama-radicals mahhala esikhumbeni. Umsebenzi we-antioxidant we-Phlorizin wehla kakhulu ngoba iqembu layo le-hydroxyl elisendaweni yesi-6 lithathelwa indawo yiqembu le-glucosidyl.
Vimbela i-tyrosinase

I-Tyrosinase iyi-metalloenzyme equkethe ithusi futhi iyi-enzyme eyinhloko ekwakhekeni kwe-melanin. Umsebenzi we-tyrosinase ungasetshenziswa ukuhlola ukuthi umkhiqizo unomphumela wokuba mhlophe yini. I-Phloretin iyi-reversible inhibitor ehlanganisiwe ye-tyrosinase. Ingavimbela i-tyrosinase ekubopheni ku-substrate yayo ngokushintsha ukwakheka kwesibili kwe-tyrosinase, ngaleyo ndlela yehlise umsebenzi wayo we-catalytic.

Umsebenzi we-antibacterial

I-Phloretin iyinhlanganisela ye-flavonoid enomsebenzi we-antibacterial. Inemiphumela evimbelayo ezinhlobonhlobo zamabhaktheriya e-Gram-positive, amagciwane e-Gram-negative kanye nesikhunta.
Imiphumela yokuhlolwa komtholampilo ibonisa ukuthi ngemva kokuba izihloko zisebenzisa i-phloretin amaviki angu-4, ama-whiteheads, ama-blackheads, ama-papules, ne-sebum secretion ancishiswa kakhulu, okubonisa ukuthi i-phloretin inamandla okukhulula induna.

3. Izithako ezinconyiwe
ingqikithi
2% i-phloretin(i-antioxidant, emhlophe) + 10% [l-ascorbic acid] (i-antioxidant, ukukhuthazwa kwe-collagen nokuba mhlophe) + 0.5%i-ferulic acid(i-antioxidant kanye nomphumela we-synergistic), ingamelana nemisebe ye-ultraviolet emvelweni, imisebe ye-infrared kanye nokulimala kwe-ozone esikhumbeni, ikhanyise ithoni yesikhumba, futhi ifaneleka kakhulu esikhumbeni samafutha ngethoni yesikhumba esimnyama.