Emkhakheni wesayensi yezimonyo, i-DL panthenol ifana nokhiye oyinhloko ovula umnyango wempilo yesikhumba. Lesi sandulela se-vitamin B5, esinemiphumela emihle kakhulu yokuthambisa, ukulungisa, kanye ne-anti-inflammatory, sesiphenduke isithako esisebenzayo esibalulekile kumafomula okunakekelwa kwesikhumba. Lesi sihloko sizocubungula izimfihlakalo zesayensi, inani lesicelo, namathemba esikhathi esizayo e-DL panthenol.
1. Ukuqoshwa kwesayensi kweI-DL panthenol
I-DL panthenol iwuhlobo lwe-racemic lwe-panthenol, enegama lamakhemikhali elithi 2,4-dihydroxy-N – (3-hydroxypropyl) -3,3-dimethylbutanamide. Isakhiwo sayo samangqamuzana siqukethe iqembu elilodwa eliyisisekelo lotshwala kanye namaqembu amabili esibili otshwala, okulinikeza i-hydrophilicity enhle kakhulu kanye nokungena.
Inqubo yokuguqulwa esikhumbeni iyisihluthulelo sokusebenza kahle kwe-DL panthenol. Ngemva kokungena esikhumbeni, i-DL panthenol iguqulwa ngokushesha ibe i-pantothenic acid (i-vitamin B5), ebamba iqhaza ekuhlanganiseni i-coenzyme A, ngaleyo ndlela ithinte i-fatty acid metabolism kanye nokwanda kwamangqamuzana. Ucwaningo luye lwabonisa ukuthi izinga lokuguqulwa kwe-DL panthenol ku-epidermis lingafinyelela ku-85%.
Umsebenzi oyinhloko wesenzo uhlanganisa ukuthuthukisa umsebenzi wokuvimbela isikhumba, ukukhuthaza ukwanda kwamaseli e-epithelial, nokuvimbela ukuphendula kokuvuvukala. Idatha yokuhlola ibonisa ukuthi ngemva kokusebenzisa umkhiqizo oqukethe i-5% DL panthenol amaviki angu-4, ukulahlekelwa kwamanzi e-transdermal esikhumbeni kunciphisa ngo-40%, futhi ubuqotho be-stratum corneum buthuthukisiwe kakhulu.
2. Ukusetshenziswa kwe-Multidimensional yeI-DL panthenol
Emkhakheni we-moisturizing, i-DL panthenol ithuthukisa ukugeleza kwe-stratum corneum futhi ikhulise umswakama wesikhumba. Izivivinyo zemitholampilo zibonise ukuthi ukusebenzisa i-moisturizer equkethe i-DL panthenol amahora angu-8 kwandisa umswakama wesikhumba ngo-50%.
Mayelana nokulungisa, i-DL panthenol ingakhuthaza ukwanda kwamangqamuzana e-epidermal futhi isheshise ukutakula kokusebenza kwezithiyo. Ucwaningo luye lwabonisa ukuthi ukusetshenziswa kwe-postoperative yemikhiqizo equkethe i-DL panthenol kunganciphisa isikhathi sokuphulukiswa kwesilonda ngo-30%.
Ngokunakekelwa kwemisipha ebucayi, imiphumela elwa nokuvuvukala nepholile ye-DL panthenol igqame kakhulu. Ukuhlolwa kubonise ukuthi i-DL panthenol ingavimbela ukukhululwa kwezinto ezivuthayo ezifana ne-IL-6 ne-TNF - α, ukunciphisa ukubomvu kwesikhumba nokucasuka.
Ekunakekelweni kwezinwele, i-DL panthenol ingangena ezinweleni futhi ilungise i-keratin eyonakele. Ngemva kokusebenzisa imikhiqizo yokunakekelwa kwezinwele equkethe i-DL panthenol amasonto angu-12, amandla okuphuka kwezinwele akhuphuke ngo-35% futhi ukucwebezela kwaba ngcono ngo-40%.
3. Amathemba esikhathi esizayo we-DL panthenol
Ubuchwepheshe obusha bokuqamba obufana nama-nanocarriers nama-liposomes buthuthukise kakhulu ukuzinza kanye nokutholakala kwe-bioavailabilityI-DL panthenol. Isibonelo, ama-nanoemulsions angakhuphula ukuvuthwa kwesikhumba se-DL panthenol izikhathi ezi-2.
Ucwaningo lwesicelo somtholampilo luyaqhubeka nokujula. Ucwaningo lwakamuva lubonisa ukuthi i-DL panthenol inenani elingase libe khona ekwelapheni kwe-adjuvant yezifo zesikhumba njenge-atopic dermatitis kanye ne-psoriasis. Isibonelo, ukusetshenziswa kwe-DL panthenol equkethe ukwakheka ezigulini ezine-atopic dermatitis kunganciphisa izikolo zokulunywa ngo-50%.
Amathemba emakethe abanzi. Kulindeleke ukuthi ngo-2025, usayizi wemakethe ye-DL panthenol emhlabeni wonke ufinyelele ezigidini ezingama-350 zamadola aseMelika, ngezinga lokukhula lonyaka elingaphezu kuka-8%. Ngokukhula kwesidingo sezithako ezisebenzayo ezithambile ezivela kubathengi, izindawo zokusetshenziswa ze-DL panthenol zizokhula futhi.
Ukutholakala nokusebenzisa i-DL panthenol kuvule inkathi entsha yokunakekelwa kwesikhumba. Kusukela ekunyakaziseni nasekulungiseni kuya ekunqandeni ukuvuvukala nokupholisa, kusukela ekunakekeleni ubuso kuya ekunakekeleni umzimba, lesi sithako esisebenza ngezindlela eziningi sishintsha umbono wethu ngempilo yesikhumba. Ngokuzayo, ngokuthuthuka kobuchwepheshe bokubunjwa kanye nokujula kocwaningo lwezokwelapha, i-DL panthenol ngokungangabazeki izoletha ukuqamba okusha kanye namathuba okunakekelwa kwesikhumba. Endleleni yokuphishekela ubuhle nempilo, i-DL panthenol izoqhubeka nokudlala indima yayo eyingqayizivele nebalulekile, ibhala isahluko esisha kusayensi yesikhumba.
Isikhathi sokuthumela: Mar-18-2025
