I-hyaluronate ye-sodiumitholakala kakhulu ezilwaneni nakubantu esikhumbeni somuntu, uketshezi lwe-synovial, inkaba, i-aqueous humor, kanye nomzimba we-ophthalmic vitreous. Isisindo sayo samangqamuzana singama-500 000-730 000 Dalton. Isixazululo saso sine-viscoelasticity ephezulu kanye nephrofayili. Kuyi-adjuvant yokuhlinzwa kwe-ophthalmic. Igcina ukujula okuthile kwegumbi langaphambili ngemuva kokujova egumbini elingaphambili. Ilungele ukusebenza. Iphinde ivikele amangqamuzana e-corneal endothelial kanye nezicubu ze-intraocular, inciphisa izinkinga zokusebenza, futhi ikhuthaze ukuphulukiswa kwesilonda.
Umthombo we-Sodium hyaluronate
I-hyaluronate ye-sodiumi-macromolecule polysaccharide ekhishwe emzimbeni wezinkomo vitreous. Inezici ezintathu: ukulwa nokuguga kanye nokugcinwa okusha kanye nokwamukela i-biotechnology.
I-sodium hyaluronate ingenye yezingxenye zesikhumba somuntu, i-acid mucosa esatshalaliswa kakhulu emzimbeni, ikhona ku-matrix yezicubu ezixhumeneyo, futhi inomphumela omuhle wokuthambisa.
Izici ze-Sodium hyaluronate
I-sodium hyaluronate inezici ezintathu: ukupakisha okunqanda ukuguga kanye nokugcina okusha kanye ne-biotechnology. I-Sodium hyaluronate ingenye yezingxenye zesikhumba somuntu kanye ne-mucose ene-asidi esatshalaliswa kakhulu emzimbeni womuntu. Ikhona ku-matrix yezicubu ezixhumeneyo futhi inomphumela omuhle wokuthambisa.
Izinzuzo zeSodium Hyaluronate
1. Ukwenza ngcono i-Pharmacodynamics
I-hyaluronic acidiyingxenye eyinhloko yezicubu ezixhumeneyo njenge-interstitium yomuntu, umzimba we-vitreous, noketshezi lwe-synovial. Inezici zokugcina amanzi, ukugcina indawo engaphandle kwamaseli, ukulawula ingcindezi ye-osmotic, ukugcoba, nokukhuthaza ukulungiswa kwamaseli ku-vivo. Njengomuntu ophethe izidakamizwa ze-ophthalmic, ingandisa isikhathi sokugcinwa kwezidakamizwa ebusweni beso ngokwandisa i-viscosity yamaconsi wamehlo, ukuthuthukisa ukutholakala kwezidakamizwa, nokunciphisa ukucasuka kwezidakamizwa emehlweni.
Ukwelashwa kwe-adjuvant kungajovwa ngqo emgodini we-articular njengendlela yokugcoba yokwelapha isifo samathambo, njengomjovo we-SPIT.
2. Crease Resistance
Izinga lomswakama wesikhumba lihlobene eduze nokuqukethwe kwe-hyaluronic acid. Ngokukhula kweminyaka, okuqukethwe kwe-hyaluronic acid esikhumbeni kuncipha, okwenza buthaka umsebenzi wokugcinwa kwamanzi esikhumbeni futhi kukhiqize imibimbi. Isixazululo samanzi se-sodium hyaluronate sine-viscoelasticity eqinile kanye ne-lubricity. Uma ifakwa esikhumbeni, ingakha ifilimu evumela umswakama ukugcina isikhumba simanzi futhi sicwebezela. I-molecule encane i-hyaluronic acid ingangena ku-dermis, ikhuthaze i-microcirculation yegazi, isize isikhumba ukuthi simunce imisoco, futhi idlale indima yezempilo yezimonyo nokulwa nemibimbi.
3. Umphumela Womswakama
Umphumela womswakama uyindima ebaluleke kakhului-hyaluronate ye-sodium ku-cosmetics. Uma kuqhathaniswa namanye ama-moisturizer, umswakama ohlobene wendawo ezungezile unomthelela omncane emthelela wawo wokuthambisa. Le mvelo eyingqayizivele ingashintshwa ukuze isikhumba ngezikhathi ezahlukene zonyaka, ezahlukene umswakama kwemvelo, ezifana ebusika owomile kanye nehlobo elimanzi, kanye nezidingo izimonyo moisturizing effect. Ukugcinwa komswakama we-sodium hyaluronate kuhlobene nesisindo sayo nesisindo samangqamuzana.
4. Imiphumela Yokudla Okunempilo
I-sodium hyaluronate iyinto engokwemvelo yemvelo esikhumbeni, futhi i-sodium hyaluronate yangaphandle iyisengezo se-endogenous sodium hyaluronate esikhumbeni. I-hyaluronate ye-sodium enekhwalithi ephansi ingangena ku-epidermis yesikhumba, ikhuthaze ukunikezwa kokudla okunomsoco wesikhumba kanye nokukhishwa kwemfucuza, ngaleyo ndlela ivimbele ukuguga kwesikhumba, futhi ibambe iqhaza ku-cosmetology nobuhle. Ukunakekelwa kwesikhumba kubaluleke kakhulu kunezinye izimonyo futhi sekuyisifiso sabantu besimanje sokugcina ukwazi kobuso.
5. Ukulungisa Nokuvinjelwa Kokulimala Kwesikhumba
Isikhumba sishiswa noma sishiswe ukukhanya kwelanga, njengokubomvu, ukuba mnyama, ukuxebuka, njll., ikakhulukazi imisebe ye-ultraviolet ekukhanyeni kwelanga. I-sodium hyaluronate ingakhuthaza ukuvuselelwa kwesikhumba esilimele ngokukhuthaza ukwanda nokuhlukaniswa kwamangqamuzana e-epidermal kanye nokukhipha ama-radicals angenawo umoya-mpilo. Ukusetshenziswa kwangaphambili nakho kunomphumela wokuvimbela. Indlela yokusebenza kwayo ihlukile kunento emunca i-ultraviolet evame ukusetshenziswa ekukhiqizweni kwelanga. Ngakho-ke, i-hyaluronic acid kanye ne-ultraviolet absorbent emikhiqizweni ye-skincare ye-sunscreen inomphumela we-synergistic, onganciphisa ukudluliswa kwemisebe ye-ultraviolet futhi ulungise umonakalo wesikhumba obangelwa inamba encane yemisebe ye-ultraviolet, ngaleyo ndlela idlala indima yokuvikela kabili.
Inhlanganisela ye-sodium hyaluronate ne-EGF (i-epidermal growth factor) ingasheshisa ukuvuselelwa kwamangqamuzana e-epidermal futhi yenze isikhumba sibe ithenda, sibushelelezi futhi sinwebeka. Lapho isikhumba sihlushwa ukusha okuncane kanye nama-scalds, ukusetshenziswa kwezimonyo zamanzi ezine-sodium hyaluronate ebusweni kungadambisa ubuhlungu futhi kusheshise ukuphulukiswa kwesikhumba esilimele.
6. Ukugcotshwa kanye Nokwakhiwa Kwefilimu
I-sodium hyaluronate iwuhlobo lwe-polymer enokuthambisa okuqinile nezici zokwenza ifilimu. Imikhiqizo yokunakekelwa kwesikhumba equkethe i-sodium hyaluronate inokuthambisa okusobala nomuzwa omuhle wesandla uma isetshenziswa. Uma isetshenziswa esikhumbeni, ifilimu ingakhiwa ebusweni besikhumba, okwenza isikhumba sizizwe sibushelelezi futhi simanzi, futhi sivikela isikhumba. Imikhiqizo yokunakekelwa kwezinwele equkethe i-sodium hyaluronate ingenza ungqimba lwefilimu ebusweni bezinwele, engakwazi ukuthambisa, ukugcoba, ukuvikela izinwele, ukuqeda ugesi omile, nokwenza izinwele zibe lula ukukama, zinhle, futhi zemvelo.
7. Ukujiya
I-sodium hyaluronate ine-viscosity ephezulu kwisisombululo esinamanzi. Ingadlala indima yokuqina nokuqiniswa kwezimonyo.
8. I-Pharmacological Effects ye-Sodium Hyaluronate
Izinto ezisebenzayo ze-physiological zikhona ezilwaneni nakubantu futhi zisakazwa esikhumbeni somuntu, uketshezi lwe-synovial lwamalunga, intambo ye-umbilical, i-aqueous humor, ne-vitreous body of eyes. Isisindo samangqamuzana yi-500000-730000 Dalton. Isixazululo saso sine-viscoelasticity ephezulu nokulingisa. Kuyi-adjuvant yokuhlinzwa kwe-ophthalmic. Igcina ukujula okuthile kwegumbi langaphambili ngemuva kokujova egumbini elingaphambili, elilungele ukusebenza. Iphinde ivikele amangqamuzana e-corneal endothelial kanye nezicubu ze-intraocular, inciphisa izinkinga, futhi ikhuthaze ukuphulukiswa kwesilonda.
Isikhathi sokuthumela: Aug-23-2023