I-Ferulic acidiyinhlanganisela yemvelo etholakala ezinhlobonhlobo zezitshalo ezifana ne-Angelica sinensis, i-Ligusticum chuanxiong, i-horsetail kanye nemithi yendabuko yamaShayina, futhi ithole ukunakwa kwezindawo zayo ezizuzisayo. Ibuye itholakale ku-rice husk, kubhontshisi we-pandan, i-wheat bran kanye ne-rice bran. Le asidi ephilayo ene-acidic ebuthakathaka inesakhiwo se-phenolic acid futhi isebenza njenge-tyrosinase inhibitor. Lapho kuhlanganiswa nama-antioxidants anamandla afana ne-resveratrol kanyeuvithamini C, i-ferulic acid inezinzuzo eziningi ezifana nokwenza mhlophe kwesikhumba, ukuvikelwa kwe-antioxidant, ukuvimbela ukushiswa yilanga, kanye nemiphumela eqeda ukuvuvukala.
Elinye lamakhono aphawulekayo we-ferulic acid yizinto zayo zokulwa ne-antioxidant. Isakhiwo sayo se-phenolic hydroxyl siyenza iphumelele ngokumelene nama-radicals mahhala, okuhlanganisa ama-superoxide radicals nama-hydroxyl radicals. Ngokuthatha ipheya eyodwa yama-electron kuma-radicals mahhala, i-ferulic acid igxilisa i-molecule futhi ivimbele ukudluliswa kwama-electron, ivikela umzimba emonakalweni we-oxidative. Ukwengeza, i-ferulic acid inobudlelwane obuqinile be-Fe2 +, okuzobangela ukusabela kwe-redox futhi kunciphise i-Fe2 +, edlala indima ebalulekile ekusebenzeni kwe-antioxidant. Kuyathakazelisa ukuthi ikhono layo lokunciphisa i-Fe3+ compounds lidlula lelouvithamini C.
Ngaphezu kwezinzuzo zayo ze-antioxidant, i-ferulic acid nayo inezindawo ezimhlophe. I-compound ayivimbi kuphela umsebenzi we-melanocyte B16V kodwa futhi ivimbela umsebenzi we-tyrosinase, inikeza indlela ekabili yokuzuza isikhumba esimhlophe. Isixazululo esiqukethe i-5 mmol/L i-ferulic acid ivimbe umsebenzi we-tyrosinase ngama-86%. Ngisho nasekugxilweni okuphansi kuka-0.5mmol/L, i-ferulic acid isabonisa izinga elibalulekile lokuvinjelwa elingaba ngu-35% emsebenzini we-tyrosinase.
Ngaphezu kwalokho, i-ferulic acid nayo inezindawo zokuvikela ilanga. Ivikela isikhumba emisebeni yelanga eyingozi, inikeza ungqimba olwengeziwe lokuzivikela emonakalweni welanga. Lokhu kuyenza ibe isithako esifanelekile kuukuvikela ilangaimikhiqizo kanye namanye amafomula okunakekela isikhumba aklanyelwe ukunciphisa izinkinga zesikhumba ezihlobene ne-UV.
Okokugcina, i-ferulic acid iboniswe ukuthi inezinto zokulwa nokuvuvukala. Ngokunciphisa ukuvuvukala, kungasiza ukukhulula izimo zesikhumba ezinjengobomvu, ukucasuka, nokuvuvukala. Ngakho-ke, ukwengeza i-ferulic acid emikhiqizweni yokunakekelwa kwesikhumba kunomthelela empilweni yonke yesikhumba kanye nokuphila kahle.
Kafushane, i-ferulic acid itholakala ngobuningi ezinhlobonhlobo zezitshalo nemithombo yemvelo futhi inezinzuzo eziningi esikhumbeni. Ukusuka emandleni anamandla okulwa ne-antioxidant kuye ekubeni mhlophe, ukuvikela ilanga kanye nezindawo zokulwa nokuvuvukala, i-ferulic acid iyisithako esisebenza ngezindlela eziningi esingathuthukisa ukusebenza kwemikhiqizo yokunakekelwa kwesikhumba futhi sikhuthaze isikhumba esinempilo.
Isikhathi sokuthumela: Oct-30-2023
