I-Panthenol iphuma ku-vitamin B5, eyaziwa nangokuthi i-retinol B5. I-Vitamin B5, eyaziwa nangokuthi i-pantothenic acid, inezinto ezingazinzile futhi ithinteka kalula izinga lokushisa nokwakheka, okuholela ekwehleni kwe-bioavailability yayo. Ngakho-ke, isandulela sayo, i-panthenol, ivame ukusetshenziswa ekwakhiweni kwezimonyo.
Uma kuqhathaniswa ne-vitamin B5/pantothenic acid, i-panthenol inezinto ezizinzile nesisindo samangqamuzana angama-205 kuphela. ukuze kuhlanganiswe i-coenzyme A.I-CoenzymeI-A iyisici esiwusizo ezindleleni ezihlukahlukene zokusabela kwe-enzyme emzimbeni. Ibamba iqhaza kumetabolism yamandla eselula, inikeze amandla emisebenzini yokuphila komzimba. Ngaphezu kwalokho, iphinde ibambe iqhaza kumetabolism yezingxenye ezibalulekile esikhumbeni, njenge-cholesterol, ama-fatty acids, kanye ne-sphingolipids synthesis.
Ukusetshenziswa kwezihloko ze-panthenol esikhumbeni kwaqala ngo-1944 futhi kunomlando weminyaka engaphezu kwengu-70. Isetshenziswa kakhulu kuzimonyo ngenhloso yokuthambisa, ukuthambisa, nokulungisa izinjongo.
Indima ebaluleke kakhulu
Ukuswakamakanye nokwenza ngcono izithiyo
I-Panthenol ngokwayo inemisebenzi yokumuncwa nokugcina umswakama, kuyilapho ikhuthaza ukuhlanganiswa kwe-lipid, ikhulisa uketshezi lwama-molecule e-lipid nama-microfilaments e-keratin, ithuthukisa indawo eqinile phakathi kwama-keratinocyte, futhi isiza ekugcineni umsebenzi wokuvimbela isikhumba esinempilo. Kumele kuqashelwe ukuthi ukuze i-panthenol ithuthukise umphumela wesithiyo, ukugxila kufanele kube ngu-1% noma ngaphezulu, ngaphandle kwalokho i-0.5% ingaba umphumela womswakama kuphela.
Kuyaphola
Umthelela opholile we-panthenol ikakhulukazi uvela ezicini ezimbili: ① ukuvikela emonakalweni wengcindezi ye-oxidative ② ukuncishiswa kwempendulo yokuvuvukala.
① I-Panthenol inganciphisa ukukhiqizwa kwezinhlobo zomoya-mpilo osebenzayo emangqamuzaneni esikhumba, kuyilapho ilawula indlela yokulwa ne-antioxidant yesikhumba, okuhlanganisa ukunxenxa amangqamuzana esikhumba ukuthi aveze i-antioxidant factor eyengeziwe - i-heme oxygenase-1 (HO-1), ngaleyo ndlela ithuthukise umthamo we-antioxidant wesikhumba I-Pantothenic acid. kunganciphisa impendulo yokuvuvukala. Ngemuva kokuvuselela ama-keratinocyte nge-capsaicin, ukukhululwa kwezici ezivuthayo i-IL-6 ne-IL-8 kukhula kakhulu. Kodwa-ke, ngemuva kokwelashwa nge-pantothenic acid, ukukhululwa kwezici ezivuthayo kungavinjelwa, ngaleyo ndlela kunciphise impendulo yokuvuvukala futhi kukhulule ukuvuvukala.
Nyusaukulungisa
Lapho ukuhlushwa kwe-panthenol kuphakathi kuka-2% no-5%, kungakhuthaza ukuvuselelwa kwesikhumba somuntu esonakele. Ngemva kokwelapha imodeli yokulimala kwe-laser nge-panthenol, ukubonakaliswa kwe-Ki67, umaka wokwanda kwe-keratinocyte, kwanda, okubonisa ukuthi ama-keratinocyte amaningi angena esimweni sokwanda futhi akhuthaze ukuvuselelwa kwe-epidermal. Phakathi naleso sikhathi, ukuvezwa kwe-filaggrin, umaka obalulekile wokuhlukaniswa kwe-keratinocyte kanye nomsebenzi wokuvimbela, nakho kwanda, okubonisa ukukhuthazwa kokulungiswa kwesithiyo sesikhumba. Ucwaningo olusha ngo-2019 lubonise ukuthi i-panthenol ikhuthaza ukuphulukiswa kwesilonda ngokushesha kunamafutha amaminerali futhi ingathuthukisa izibazi.
Isikhathi sokuthumela: Aug-30-2024
