|Uchungechunge Lwesayensi Yokunakekelwa Kwesikhumba| I-Niacinamide (uvithamini B3)

I-Niacinamide (I-panacea emhlabeni wokunakekelwa kwesikhumba)

I-Niacinamide, eyaziwa nangokuthi i-vitamin B3 (VB3), iwuhlobo lwe-niacin olusebenzayo futhi lutholakala kabanzi ezilwaneni nasezitshalweni ezihlukahlukene. Kuphinde kube isandulela esibalulekile se-cofactors i-NADH (i-nicotinamide adenine dinucleotide) ne-NADPH (i-nicotinamide adenine dinucleotide phosphate). Kanye ne-NADH ne-NADPH encishisiwe, asebenza njengama-coenzymes ekuphenduleni kwamakhemikhali e-biochemical angaphezu kwama-40 futhi aphinde asebenze njengama-antioxidants.

Ngokomtholampilo, isetshenziselwa ikakhulukazi ukuvimbela nokwelapha i-pellagra, i-stomatitis, i-glossitis nezinye izifo ezihlobene.

indima ebaluleke kakhulu
1.Ukukhanya kwesikhumba nokuba mhlophe

I-Nicotinamide ingakwazi ukulawula ukuthuthwa kwama-melanosomes ukusuka ku-melanocyte kuya ku-keratinocyte ngaphandle kokuvimbela umsebenzi we-tyrosinase noma ukwanda kwamaseli, ngaleyo ndlela kuthinte umbala wesikhumba. Kungase futhi kuphazamise ukuxhumana phakathi kwe-keratinocyte nama-melanocyte. Iziteshi zokubonisa amaseli phakathi kwamaseli zinciphisa ukukhiqizwa kwe-melanin. Ngakolunye uhlangothi, i-nicotinamide ingasebenza ku-melanin esivele isikhiqiziwe futhi inciphise ukudluliswa kwayo kumaseli angaphezulu.

Omunye umbono ukuthi i-nicotinamide nayo inomsebenzi we-anti-glycation, onganciphisa umbala ophuzi wamaprotheni ngemva kwe-glycation, okuzosiza ekuthuthukiseni umbala wesikhumba sobuso obunemibala yemifino ngisho "nabesifazane abanobuso obuphuzi".
Nweba ukuqonda

Uma i-niacinamide isetshenziswa njengesithako esenza mhlophe, ekuhlanganiseni kuka-2% kuya ku-5%, kufakazelwe ukuthi iyasebenza ekwelapheni i-chloasma kanye ne-hyperpigmentation ebangelwa imisebe ye-ultraviolet.

2.Anti-ukuguga, ukuthuthukisa imigqa emihle (ama-anti-free radicals)

I-Niacinamide ingashukumisa ukwakheka kwe-collagen (yandise isivinini kanye nenani le-collagen synthesis), yandise ukunwebeka kwesikhumba, futhi yehlise ukubukeka kwemigqa emincane nemibimbi. Iphinde ibe nezindawo zokulwa ne-antioxidant ezinciphisa ama-radicals mahhala futhi ibambezele inqubo yokuguga kwesikhumba.
Nweba ukuqonda

Ucwaningo luye lwabonisa ukuthi ukusebenzisa i-nicotinamide (okuqukethwe okungu-5%) kunganciphisa imibimbi, i-erythema, ukuphuzi kanye namabala esikhumbeni sobuso esiguga.

3.Lungisa isikhumbaumsebenzi wokuvimba
Ukulungiswa kwe-Niacinamide komsebenzi wokuvimbela isikhumba kubonakala kakhulu ezicini ezimbili:

① Thuthukisa ukwakheka kwe-ceramide esikhumbeni;

②Sheshisa ukuhlukaniswa kwamaseli e-keratin;
Ukusetshenziswa kwe-nicotinamide ngezihloko kungakhuphula amazinga amafutha amahhala nama-ceramides esikhumbeni, kushukumise ukujikeleza kwe-microcirculation kudermis, futhi kuvimbele ukulahlekelwa umswakama wesikhumba.

Iphinde ikhulise amaprotheni synthesis (njenge-keratin), ikhulise amazinga e-NADPH ye-intracellular (nicotinamide adenine dinucleotide phosphate), futhi isheshise ukuhlukaniswa kwe-keratinocyte.
Nweba ukuqonda

Amandla okuthuthukisa umsebenzi wokuvimbela isikhumba okukhulunywe ngenhla asho ukuthi i-niacinamide inamandla okuthambisa. Ucwaningo oluncane lukhombisa ukuthi u-2% we-niacinamide wesihloko usebenza kakhulu kune-petroleum jelly (i-petroleum jelly) ekwehliseni ukulahleka kwamanzi esikhumbeni kanye nokwandisa ukugeleza kwamanzi.

Inhlanganisela engcono kakhulu yezithako
1. Inhlanganisela yokususa i-whitening ne-freckle: niacinamide +retinol A
2. Inhlanganisela yokuthambisa ejulile:i-hyaluronic acid+ squalane