Kungani i-Hydroxypinacolone Retinoate (HPR) yaziwa njengephayona ekuthuthukiseni ikhwalithi yesikhumba i-Hydroxypinacolone Retinoate (HPR) iphuma phambili emkhakheni wama-retinoids osekudonse ukunakwa okukhulu ngokusebenza kwayo okuvelele
ngcono izinga lesikhumba.
Njengamanye ama-retinoid aziwayo afana ne-retinoic acid esters kanye ne-retinal, i-HPR igqama ngekhono layo elihle lokuhlinzeka ngezinzuzo ezimangalisayo zesikhumba kuyilapho inciphisa ukucasuka. Ama-retinoids ayikilasi lezinhlanganisela ezithathwe kuvithamini A osekunesikhathi eside zihlonishwa kakhulu kwezesikhumba ngenxa yokuphumelela kwazo ekubhekaneni nokukhathazeka okuhlukahlukene kwesikhumba okufana nezinduna, umbala nezimpawu zokuguga.
Phakathi kwama-retinoid, i-retinoic acid esters kanye ne-retinal kubonise imiphumela ethembisayo. Kodwa-ke, ama-retinoids endabuko avame ukuhlotshaniswa nokucasuka kwesikhumba kanye nesikhathi sokujwayela isikhathi eside, okuye kwabangela ukuba kuthungwe ezinye izindlela ezingasetshenziswa esikhumbeni. Kulapho i-Hydroxypinacolone Retinoate (HPR) iba isiguquli segeyimu. I-HPR iyi-all-trans retinoic acid ester ebopha ngokuqondile kuma-retinoid receptors esikhumbeni. Lesi senzo esiqondile siholela emiphumeleni esheshayo nephumelelayo kunamanye ama-retinoid adinga ukuguqulwa ngaphakathi kwesikhumba ukuze kusebenze. Enye yezinzuzo eziyinhloko ze-HPR yikhono layo lokuvuselela ukuvuselelwa kweseli kanye nokuhlanganiswa kwe-collagen kuyilapho kuncishiswa imiphumela engemihle evamile njengokubomvu, ukubhakuzisa nokoma. Lokhu kukwenza kube ukukhetha okufanele kakhulu kulabo abanesikhumba esibucayi noma labo abasha ekwelashweni kwe-retinoid.
Ngaphezu kwalokho, ukuzinza kwe-HPR kuyisici esiphawulekayo. Ngokungafani namanye ama-retinoid alulaza ngokushesha futhi alahlekelwa ukusebenza kwawo, i-HPR igcina amandla ayo, iqinisekisa imiphumela engaguquki nethembekile ngokuhamba kwesikhathi. Ngakho-ke, ukufakwa kwe-HPR ekwakhiweni kokunakekelwa kwesikhumba kuphawula intuthuko enkulu, ihlinzeka ngesixazululo esisebenzayo kodwa esimnene sokuthuthukisa ukuthungwa kwesikhumba, ukunciphisa imigqa emihle kanye nokukhuthaza ithoni yesikhumba esilinganayo. Njengoba abasebenzisi beqhubeka nokufuna ukunakekelwa kwesikhumba okuphumelelayo nokubekezelelwa kahle, i-hydroxypinacolone retinate cishe izogcina isikhundla sayo njengesithako esiphayona esizoshintsha indlela esibhekana ngayo nokunakekelwa kwesikhumba. Kafushane, ukusungulwa kwe-hydroxypinacolone retinate (HPR) ilele esakhiweni sayo esiyingqayizivele kanye nekhono lokubopha i-receptor eliqondile, eliletha ngempumelelo izinzuzo zokulwa nokuguga ezifunwayo kanye nokuvuselelwa kwesikhumba. Lokhu kwenza i-HPR ibe yingqalabutho ekuthuthukisweni okuqhubekayo kwemikhiqizo okuhloswe ngayo ukuzuza isikhumba esinempilo, esibukeka sisincane.
Isikhathi sokuthumela: Nov-18-2024
