I-Urolithin A, Ithuthukisa Ukuqina Kwesikhumba Sesikhumba, Ivuselela I-Collagen, Nezimpawu Zokuguga Eziphikisayo

Urolithin A

Incazelo emfushane:

I-Urolithin A iyi-metabolite enamandla ye-postbiotic, ekhiqizwa lapho amagciwane amathumbu ephula ama-ellagitannins (atholakala kumahalananda, amajikijolo namantongomane). Ekunakekelweni kwesikhumba, kubungazwa ukwenziwa kusebenzei-mitophagy-inqubo "yokuhlanza" yeselula esusa i-mitochondria eyonakele. Lokhu kuthuthukisa ukukhiqizwa kwamandla, ukulwa nengcindezi ye-oxidative, futhi kukhuthaze ukuvuselelwa kwezicubu. Ilungele isikhumba esikhulile noma esikhathele, iletha imiphumela yokuguqula ukuguga ngokubuyisela ubungqabavu besikhumba ngaphakathi.

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Urolithin Ai-metabolite ekhiqizwa amagciwane e-gut avela e-ellagitannins-ama-polyphenols ngokwemvelo atholakala kumahalananda, amajikijolo namantongomane. Lesi sakhi saziwa ngokusebenza kwaso okukhethekile, lesi sithako sesiqhamuke njengentuthuko ekwenziweni kwezimonyo, esinikeza indlela esekelwe isayensi yokuvuselela isikhumba.UrolithinI-A isebenza ezingeni lamaselula ukusekela impilo ye-mitochondrial, "izindlu zamandla" zamangqamuzana esikhumba, abalulekile ekukhiqizeni amandla nokulungisa izicubu. Ngokuthuthukisa ukusebenza kwe-mitochondrial, kusiza ukuvuselela isikhumba esikhathele, esicindezelekile, ukunciphisa ukubukeka kokukhathala nokubuyisela ukukhanya okukhazimulayo, kobusha. Ikhono layo lokuvuselela i-collagen ne-elastin synthesis liqinisa ngokwengeziwe uhlaka lwesakhiwo sesikhumba, linciphise imigqa ecolekile, imibimbi kanye nokuwohloka.UrolithinU-A uzinzile ekwakhekeni okuhlukahlukene, kusukela kumaserum angasindi ukuya kokhilimu abacebile. Ihlanganisa ngaphandle komthungo nezinye izithako ezisebenzayo njenge-hyaluronic acid, uvithamini C, ne-retinol, ithuthukisa ukusebenza kahle kwazo kuyilapho igcina ukuhambisana kwesikhumba.

Umsebenzi Obalulekile we-Urolithin A:

Ithuthukisa umsebenzi we-mitochondrial kumaseli esikhumba ukuze kukhuliswe ukukhiqizwa kwamandla

Ivuselela i-collagen ne-elastin synthesis yokwenza ngcono ukuqina kwesikhumba

Yehlisa ingcindezi ye-oxidative futhi inciphise ama-radicals mahhala

Isekela umsebenzi wokuvimbela isikhumba kanye nokugcinwa kwe-hydration

Yehlisa izimpawu zokuguga (imigqa emihle, imibimbi, ubuthuntu).

Indlela YokwenzaUrolithin A:

I-Urolithin A isebenzisa imiphumela yayo ngezindlela eziningi:

Ukusekelwa Kwe-Mitochondrial: Kwenza kusebenze i-mitophagy-inqubo yemvelo lapho amangqamuzana asusa i-mitochondria eyonakele futhi esikhundleni sawo afake amasha, asebenzayo. Le nqubo yokuvuselela ithuthukisa ukukhiqizwa kwamandla kwamangqamuzana, ithuthukise ikhono lesikhumba lokulungisa nokuvuselela kabusha

I-Antioxidant Defence: Njenge-antioxidant enamandla, isusa ama-radicals mahhala akhiqizwa ukuchayeka kwe-UV kanye nengcindezi yendawo ezungezile, ivimbele ukulimala kwe-oxidative kumaseli esikhumba kanye ne-DNA.

I-Collagen Activation: Ilawula izakhi zofuzo ezihilelekile ekukhiqizweni kwe-collagen ne-elastin (isb, i-COL1A1, i-ELN), iqinisa i-matrix engaphandle kweseli futhi ithuthukise ukunwebeka kwesikhumba.

I-Inflammation Modulation: Inciphisa ama-cytokines abangela ukuvuvukala, isikhumba esipholile esicasuliwe futhi isekele ibala elinokulinganisela, elinempilo.

Izinzuzo kanye Nezinzuzo ze-Urolithin A:

Ukusebenza Okusekelwe Isayensi: Kusekelwa izifundo zangaphambi komtholampilo ezibonisa ubungqabavu besikhumba obuthuthukisiwe kanye nezimpawu zokuguga ezincishisiwe.

Umsuka Wemvelo: Isuselwa ku-ellagitannins esekwe ezitshalweni, ekhanga abathengi abahlanzekile bobuhle.

Ukuvumelana Okuhlukahlukene: Isebenza ngezindlela ezihlukahlukene (ama-serum, okhilimu, imaski) futhi ihlanganisa nezinye izinto ezisebenzayo.

Imiphumela Yesikhathi Eside: Ikhuthaza impilo yesikhumba ehlala njalo ngokubhekana nokuguga ezingeni lamaselula, hhayi nje izimpawu ezingaphezulu.

I-Skin-Friendly: Ayicasuli futhi ifanele isikhumba esibucayi uma isetshenziswa ezindaweni ezinconyiwe

IMICIMBI YOBUCHWEPHESHE

IZINTO	SIMICIMBI
Ukubukeka	Okumhlophe okumhlophe ukuya kokumpunga okukhanyayo
Ukuhlonza	I-HNMR iqinisekisa ukwakheka
I-LCMS	I-LCMS Ihambisana ne-MW
Ubumsulwa (HPLC)	≥98.0%
Amanzi	≤0.5%
I-Residue Ignition	≤0.2%
Pb	≤0.5ppm
As	≤1.5ppm
Cd	≤0.5ppm
Hg	≤0.1ppm
E.Coli	Okubi
I-Methanol	≤3000ppm
I-TBME	≤1000ppm
I-Toluene	≤890ppm
I-DMSO	≤5000ppm
I-Acetic Acid	≤5000ppm